Research carried out on Monoclonal Antibodies
A major breakthrough in medical science was the discovery of monoclonal antibody therapy, where antibodies that specifically bind to target cells are used to stimulate the patient's natural immune system to fight against these cells. Various research activites are being carried out on this field because if it is possible to produce a monoclonal antibody which is specific to extracellular substances, it can be used as a treatment for serious diseases like multiple sclerosis, rheumatoid arthritis and even cancer.
Monoclonal antibodies can used through two mechanisms, direct and indirect mechanism. Directly by inducing programmed cell death or apoptosis by blocking growth factor receptors to stop proliferation and indirectly by using antibody mediated cell death, making use of macrophages and monocytes to destroy target cells.