New form of cell death.

10/05/2011 20:32

Peter Kreuzaler's PHD research at the Department of pathology at the university of cambridge, has discorved another form of cell death. Their research showed that cells in the breast die following lactation by a process that involves lysosomes-organelles which digest and recycle cellular components. Through their work the proved that as mammary glands regresses, enzymes called cathepsins leak out of the lysosomes into the cell and induce cell death. They found that in cancers that have poor prognosis high levels of Stat 3 was observed down regulating a gene that inhibits lysosomal enzymes.

This discovery hopefully would lead to an explanation for the yet unexplained tumor resistance to cell death, and give researcherd new prospective therapeutic targets.